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   > (GO:0003674) molecular_function [10671, 18 ][dist]
         > (GO:0003824) catalytic activity [4605, 555 ][dist]
               > (GO:0016853) isomerase activity [117, 44 ][dist]
                     > (GO:0003916) DNA topoisomerase activity [13, 3 ][dist]

   > (GO:0003674) molecular_function [10671, 18 ][dist]
         > (GO:0005488) binding [6378, 250 ][dist]
               > (GO:0003676) nucleic acid binding [2094, 790 ][dist]
                     > (GO:0003677) DNA binding [1222, 850 ][dist]
                           > (GO:0003916) DNA topoisomerase activity [13, 3 ][dist]
                                 -> (GO:0003917) DNA topoisomerase type I activity [5, 5 ][dist]
                                 -> (GO:0003918) DNA topoisomerase (ATP-hydrolyzing) activity [10, 10 ][dist]